Hong-Min Liu Selected Research

Kaurane Diterpenes

2/2022	Synthesis, biological evaluation and cellular localization study of fluorescent derivatives of Jiyuan Oridonin A.
1/2021	Jiyuan Oridonin A Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cells With MLL Rearrangements via Multiple Signaling Pathways.
12/2020	Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents.
9/2020	OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma.
11/2019	Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate.
4/2019	A novel ent-kaurane diterpenoid analog, DN3, selectively kills human gastric cancer cells via acting directly on mitochondria.
11/2017	Gene expression profiling and pathway network analysis of anti-tumor activity by Jaridon 6 in esophageal cancer.
1/2017	OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma.
12/2016	Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species.
7/2013	Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hong-Min Liu Research Topics

Disease

104	Neoplasms (Cancer) 07/2022 - 10/2008
30	Stomach Neoplasms (Stomach Cancer) 06/2022 - 11/2013
7	Esophageal Neoplasms (Esophageal Cancer) 03/2018 - 07/2013
6	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 10/2011
5	Neoplasm Metastasis (Metastasis) 07/2022 - 09/2015
4	Carcinogenesis 04/2021 - 06/2013
4	Esophageal Squamous Cell Carcinoma 09/2020 - 01/2016
3	Breast Neoplasms (Breast Cancer) 01/2022 - 10/2011
3	Inflammation (Inflammations) 07/2021 - 12/2016
3	Carcinoma (Carcinomatosis) 01/2021 - 11/2016
2	Melanoma (Melanoma, Malignant) 01/2022 - 03/2021
2	Urinary Bladder Neoplasms (Bladder Cancer) 03/2021 - 11/2014
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 01/2020
2	Acute Promyelocytic Leukemia 01/2021 - 01/2021
2	Infarction (Infarctions) 07/2019 - 05/2014
2	Neuroblastoma 05/2016 - 10/2011
2	Infections 08/2014 - 06/2013
2	Pulmonary Arterial Hypertension 03/2012 - 12/2010
1	Peripheral Nervous System Diseases (PNS Diseases) 07/2021
1	Hyperalgesia 07/2021

Drug/Important Bio-Agent (IBA)

20	Lysine (L-Lysine)FDA Link 06/2022 - 06/2013
14	Pharmaceutical PreparationsIBA 02/2022 - 11/2013
13	DiterpenesIBA 02/2022 - 07/2013
13	pyrimidineIBA 02/2021 - 11/2013
11	Biological ProductsIBA 05/2022 - 11/2013
10	Histones (Histone)IBA 06/2022 - 06/2013
10	Kaurane DiterpenesIBA 02/2022 - 07/2013
9	Proteins (Proteins, Gene)FDA Link 07/2022 - 01/2017
7	oridoninIBA 02/2022 - 11/2016
7	Fluorouracil (Carac)FDA LinkGeneric 01/2017 - 04/2013
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2013
5	EnzymesIBA 01/2022 - 06/2013
5	Histone DemethylasesIBA 01/2022 - 01/2017
5	Paclitaxel (Taxol)FDA LinkGeneric 07/2021 - 11/2013
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2022 - 02/2020
4	indoleIBA 01/2021 - 12/2019
4	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2019 - 07/2013
4	Antineoplastic Agents (Antineoplastics)IBA 01/2018 - 06/2010
4	Chalcone (Benzalacetophenone)IBA 01/2017 - 03/2015
3	B7-H1 AntigenIBA 07/2022 - 02/2020
3	DNA (Deoxyribonucleic Acid)IBA 06/2022 - 01/2018
3	snake venom protein C activatorIBA 01/2022 - 10/2020
3	Proteolysis Targeting ChimeraIBA 01/2022 - 10/2020
3	Cullin Proteins (Cullins)IBA 12/2021 - 01/2021
3	ThiosemicarbazonesIBA 01/2021 - 12/2017
3	Adenosine Triphosphate (ATP)IBA 01/2021 - 11/2019
3	NucleosidesIBA 11/2014 - 10/2008
2	Programmed Cell Death 1 ReceptorIBA 07/2022 - 03/2021
2	ChromatinIBA 06/2022 - 01/2021
2	Transcription Factors (Transcription Factor)IBA 06/2022 - 01/2021
2	jaridon 6IBA 10/2021 - 11/2017
2	CytokinesIBA 07/2021 - 07/2019
2	Deubiquitinating EnzymesIBA 04/2021 - 04/2020
2	ubiquitin-Nalpha-protein hydrolaseIBA 03/2021 - 04/2020
2	Alkynes (Acetylenes)IBA 01/2021 - 02/2015
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021 - 11/2019
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2021 - 07/2018
2	GSK2879552IBA 01/2021 - 01/2017
2	TubulinIBA 10/2020 - 10/2017
2	AmidesIBA 10/2020 - 04/2020
2	Amino Acids FDA Link 11/2019 - 11/2019
2	TriazolesIBA 11/2019 - 11/2013
2	Matrix Metalloproteinases (MMPs)IBA 04/2019 - 12/2013
2	PiperazineIBA 05/2018 - 01/2018
2	HydrazonesIBA 03/2018 - 11/2016
2	ThioureaIBA 10/2017 - 02/2015
2	geridoninIBA 02/2017 - 11/2016
2	Sirolimus (Rapamycin)FDA Link 01/2017 - 01/2016
2	2- (3- (4- ((2,6- dimethylmorpholino)methyl)styryl)- 1H- indazol- 6- yl)- 5'- methoxyspiro(cyclopropane- 1,3'- indolin)- 2'- oneIBA 01/2016 - 01/2015
2	OxindolesIBA 06/2015 - 05/2014
2	jaridoninIBA 01/2015 - 07/2013
2	Tumor Biomarkers (Tumor Markers)IBA 11/2014 - 10/2008
2	andrographolideIBA 12/2013 - 12/2011
2	Sildenafil Citrate (Viagra)FDA Link 03/2012 - 12/2010
1	Immune Checkpoint InhibitorsIBA 07/2022
1	Messenger RNA (mRNA)IBA 06/2022
1	MicroRNAs (MicroRNA)IBA 06/2022
1	Vitamin A (Retinol)FDA LinkGeneric 04/2022
1	Coloring Agents (Dyes)IBA 02/2022
1	NaphthalimidesIBA 02/2022
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2022
1	KynurenineIBA 01/2022
1	Tryptophan (L-Tryptophan)FDA Link 01/2022
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2022
1	piperidineIBA 12/2021
1	Cullin 1IBA 12/2021
1	Sirtuin 1IBA 10/2021
1	NeuropeptidesIBA 07/2021
1	p38 Mitogen-Activated Protein KinasesIBA 07/2021
1	Therapeutic UsesIBA 07/2021
1	Dinoprostone (PGE2)FDA Link 07/2021
1	AlkaloidsIBA 07/2021
1	Histone Deacetylase 6IBA 06/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2021
1	Protein Tyrosine PhosphatasesIBA 03/2021

Therapy/Procedure

33	Therapeutics 07/2022 - 12/2010
7	Drug Therapy (Chemotherapy) 04/2022 - 01/2018
4	Immunotherapy 07/2022 - 01/2021
3	Oral Administration 10/2017 - 02/2015
1	Analgesia 07/2021